11月22日是美国前总统约翰-F-肯尼迪遇刺五十周年纪念日，本片是美国国家地理频道对该事件的献礼片。电视红人Rob Lowe在本片中扮演美国前总统肯尼迪，来自《传说》的Ginnifer Goodwin扮演肯尼迪的妻子、前美国第一夫人杰奎琳（Jacqueline），Will Rothhaar扮演行刺肯尼迪的凶手Lee Harvey Oswald（注：史学家仍存在较大争议），来自《绯闻女孩》（Gossip Girl）的Michelle Trachtenberg扮演Oswald的妻子、前苏联移民Marina。本片被翻译成48种语言，在全球171个国家和地区播出。本片是国家地理频道「刺杀」系列纪录电影的第二部，上一部《刺杀林肯》获得了不错的口碑。

　　When a series of package bombs show up on the doorsteps of prominent politicians and businessmen in the summer of 1919, U.S. Bureau of Investigation Agent William Flynn (Strathairn) is assigned the task of finding those responsible. He becomes immersed in an investigation that uncovers an anarchist plot to destroy democracy. Inspired by true events of the 20s the film sets the stage for a timely thriller with resoundingly similar parallels to the contemporary war on terrorism and the role government plays to defeat it.

影片记录了人们慌忙赶往当地医院的情景、随之而来的公众混乱、目击者指认枪声来自德克萨斯州教科书仓库后执法部门迅速展开的搜捕行动，以及奥斯瓦尔德被带去审讯时媒体和当局之间的冲突和混乱